Somewhat tangential, but the floppy disc icon has become the universal indicator for "save", and yet there's a whole generation of computer users who have never used them. I have to remind myself when designing GUIs that icons can be ambiguous.
Nothing wrong with a good meme. Everything used to be skeumorphic and used pre-tech metaphors — the OS desktop being a metaphor for the literal top of a desk complete with folder icons that look like paper folders. The World Wide Web was seen as a jungle to be navigated by browsers with names like "Netscape Navigator" and "Safari". Now GUIs are imitating early technology and kids have no idea what's being imitated.
Which is good. We shouldn't forget computer history.