I think Central/South America has good long term prospects, into the 2060s at least. Countries like Ecuador are making big moves to improve their future. While a lot of the changes are controversial and risky, I think it's likely to workout positively for some of them. With current population trends it's going to be one of the last regions to have maintain positive population growth. The aging populations, and the project population declines, of the world will cause incredible strain on the economy. Being several decades behind the global trends will give them an advantage on any manufactured goods not fully automated. The most political stable and globally connected countries in the 2030s and 40s will be the winners.
Political instability, crime/corruption, changing climates, and weak military power makes investment in the area high risk. It's hard to determine which smaller countries will be breakout successes. If this river is actually clean in 3 years, this is a positive signal for Ecuador.