I have not used Xpra, so I do not know if it has any problems with this, but a priori I do not see why an application like Xpra would need to be aware about the screen resolution. That should be handled by the X clients and servers.
I have used only 4k monitors for more than 10 years in Linux and the only applications with which I frequently had problems were various programs written in Java by morons, which were usually proprietary applications and some times quite expensive, but they lacked such elementary customization features like allowing the user to change the font, or at least its size, while failing to use the configuration settings of the graphic desktop, i.e. the value set for the monitor DPI, like all non-Java programs.