I feel like I'm looking in a mirror. Everything you wrote is me 100%.
I don't think about this a lot, but perhaps I should.
https://www.geekwire.com/2023/suspect-in-alleged-stabbing-of...
I am sympathetic to the pains discussed here, but that sounds like a psychotic and deeply disturbed individual whose traits were not attributable to programming or tech in general.
Might as well have been an industrial engineer or lorry driver.
"Entfremdung" in work is a real thing, but mentioning this kind of case and thinking up associations is not doing this idea any justice.
Yes, I think a big factor was his early life and then further drug "adventures" (was put on adderall at 5 y.o. -- by his admission -- become dependent on it and then fell into meth and the rest).
If you read some of his journals I think this, and a different sort of familial alienation (which led to another sort of social alienation) led to this chain of events. An alienation nonetheless, but yes not exactly job-caused (though it cannot be ruled out as a factor).