As other mentioned, anything AI (Stable Diffusion for instance is 5.86, ComfyUI 5.19, then there is Whisper, OpenLyrics, LLM), ... this is not counting the model files of course. Some client projects are packaged in a way that bring in a lot of unneeded dependencies. They could be repackaged to be 'lite' but no one thinks this is worth the time investment and is going to pay for it.

In almost all cases venv are needed because the dependencies are brittle and changing the python version or some package version break the program.