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There is virtually no benefit and only downsides to healthy people under 40 supplementing NAD+ via any pathway.

The supplement people will still happily market/sell it to you though, old-school niacin is only 10 cents a day but fancy new NMN/NR is easily $1 a day, they are making a fortune.

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I'm iffy on niacin, after reading too much HN.

> Surprising link found between niacin and risk of heart attack and stroke

> Breakdown products of niacin, aka Vitamin B3, may spur vascular inflammation.

https://arstechnica.com/science/2024/02/surprising-link-foun...

Doesn’t niacin lead to prettt severe hot flashes / flushing of the face and extremities? I know someone who was told to take it for cholesterol (I think) and it sounded painful!

Yes, too much niacin can make your entire body flush with a burning sensation.

Niacin mega-doses have been used for decades to reduce lipids, triglycerides, etc. and yes when you take 1 gram it will causes a painful flushing.

However to simply raise NAD+ levels you can take as little as 100mg

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