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Comment by a2tech | Hacker News Reader

I sit in a lot of doctor training sessions and the feelings on hrt have changed a lot in the last 5-10 years. It’s now well thought of and an acceptable risk. Apparently the quality of life improvement is huge compared to the relatively minor risk

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Although I knew a woman who had breast cancer and a consequence was taking her off HRT. Which she was dreading.

I saw this recent video on a similar topic (prostate cancer and testerone/TRT considerations) [1], and bookmarked it for later. Not knowledgeable to speak further on it though.

[1] https://www.youtube.com/watch?v=fiVCsm4dNh0

If testosterone causes PC then men in their teens and 20s would be the most likely candidates to suffer from it. But PC is almost always a disease of old age .

Estrogen exposure is a significant risk factor for endometrial cancer, which most commonly occurs in post-menopausal women. It’s a cumulative effect, as are many other things.

Not a comment on the parent post, just highlighting that biology is not so straight forward.

It is my understanding that excess testosterone can take prostate cancer from „it grows so slowly you’ll die of something else first“ to something that kills you quickly.

What my doctor has told me, after attending a urology + prostate cancer conference, is to think of the prostate as a sponge that absorbs testosterone. And once the sponge overflows, prostate cancer can be triggered.

But once cancer has occurred, adding more testosterone doesn't matter because the sponge is already super-saturated.

In fact, doctors who have this perspective will permit men with prostate cancer to continue testosterone therapy.

My father was recently diagnosed with prostate cancer and the first treatment was eradicating all testosterone from his body as the affected cells were "feeding" from it. It's not a cure as they tend to find other ways to grow with time but testosterone does make it faster.

Of course there are many types of cancer so this may not be true for all prostate cancers.

When I reach my elder years, I would happily undergo a preemptive mastectomy in exchange for stronger bones that would let me stay mobile for longer.

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