I don’t think the “in mice” torpedo is as effective in this case. As long as the human tau protein they are modified to express is the same protein targeted in humans then the action of this antibody should be equivalent. We’re talking about extracellular processes here so it should be very similar to how it would work in any animal. ie we don’t have to worry as much about the other differences normally present inside cells of genetically modified mice. Yes there could be confounding variables present in the space between the cells but if this interaction works both in vitro and in vivo it should be generally the same anywhere. All that’s left is safety which should be determinable in the usual ways eg more animal trials.