IBM 1401. One of the weirdest ISAs I've ever read about, with basically human readable machine code thanks to BCD.
Machine code including instructions and data was all printable characters, so you could punch an executable program right onto a card, no translation needed. You could put a card in the reader, press a button, and the card image would be read into memory and executed, no OS needed. Some useful utilities -- list a card deck on the printer, copy a card deck to tape -- fit on a single card.