If you buy certain flavors of string theory, you could say that we can only tell what's going on beyond our own 'brane, as our 'brane happens to be an embedded system that we would need to step outside to understand what exists outside of it.
Essentially it seems to me that Yegge is saying that we don't know what's going on outside of our 3-space 1-time universe, and that even posing the questions from within the universe is an exercise in futility.