I'd take whatever the hell you'd give me even for a .00001% chance of it working at a 25% chance of it screwing me up further if I had Alzheimers as well.
DNA manipulation in mice, through breeding or gene editing techniques like CRISPR-Cas, allows researchers to study specific genes and diseases. Using mice is faster than conducting initial studies on humans, allowing for rapid testing of hypotheses and treatments before moving to human trials. Mice also have much shorter lifespans and faster reproductive cycles, enabling researchers to study diseases and genetic effects across multiple generations in a fraction of the time required for human studies.
Maybe if OP would like to sacrifice their children and grand children... sounds a bit insane doesn't it?
Here is a nice paper for you to read https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/
And if the experimental design calls for replicable genometypes (cases and controls) then just use sets of diverse types of F1 hybrids.
It's true but AD is likely not one disease but is many different mutations causing a family of shared symptoms which makes it hard to study. It's often better to gain a mechanistic understanding in a reductive model because you'd not have the statistical power in a mixed population to see anything at all.