Actually I was unconsciously talking about the typical Common Lisp implementations I have used.
> Still, software in most Lisp projects is organized in files.
Yes, sure, but I am not sure the combination of image, promoting interactive development mixes well with do a git commit and typical CI pipelines. Interactivity encourages a flow where you "instantly see" results and experiment, whereas a compile-edit-runtests follows more naturally with more structure in test cases, etc.
Of course they have their uses, and their very useful use cases. But I do think they should not be abused and I also think they should be the last thing to use, when nothing else will work.