Strangely enough, I think the LaTex distribution qualifies, too. I tried to install it recently, and it wanted 1 GB of disk space! That's multiple times the size of the entire system disk when LaTeX was created...
Sooner or later a lot of the web is going to run on WASM, at which point we'll have a virtual machine running in a user program running on an OS which incompletely virtualizes the bare machine (hence why we've ended up with WASM). Extra gratuitousity if the browser is an Intel binary being run on an M* processor via Rosetta translation... Maybe eventually we'll realize that the OS needs to provide a full virtual machine, complete with window to draw in, filesystem isolation like Plan 9, etc. But, inertia will probably make it take while.