Working in this area might also be good test of their technological approach, as small-molecule binding can be somewhat challenging, and even evolved biological systems can struggle to achieve high specificity.
Working in this area might also be good test of their technological approach, as small-molecule binding can be somewhat challenging, and even evolved biological systems can struggle to achieve high specificity.
Genentech set up a subsidiary with Corning (the glass company) that owns the IP for this protease and then licensed it to laundry detergent manufacturers; many billions of dollars in revenue. I think this is one of the original patents: https://patentimages.storage.googleapis.com/d9/ca/6f/2fb89ff...
Another consideration is that most protein structure prediction methods only generate the backbone, and the sidechains are modeled in afterwards. Enzyme efficiency requires sub-A level structural precision in the sidechains that are actually doing the chemistry involved in catalysis, so it could also be the case that the current backbone-centric methods aren't good enough to predict these fine-tuned interactions.