I have a Partial PNP Deficiency that makes it harder for me to break down Inosine and Guanosine (and xanthine). My PNP enzyme only functions at about 12% of most "normal" people.

Image: https://www.frontiersin.org/files/Articles/538247/fimmu-11-0...

Paper on the topic: https://www.frontiersin.org/journals/immunology/articles/10....

So how does food affect me?

They use Inosine (Inosinic acid) and Guanosine (Guanylic acid) in foods as a food additives to increase the umami.

https://www.eurofins.com/media-centre/newsletters/food-newsl...

These are also found naturally in many foods: https://www.umamiinfo.com/richfood/

When I eat these foods I cannot break these purines down and they not only cause mood issues but also an immune deficiency.

Purinergic System Dysfunction is linked to mood disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/

After going on a low specific purine diet I no longer need any of the three psychiatric medications I was on but for klonopin since there are some triggers I cannot avoid.

Food did this. Food and having a good doctor who did not give up on me. Food and knowing what my genetics are. I get that some people might benefit from Yoga, etc, but to serve a blanket statement like that is just ignorant of the genetic and environmental diversity of humanity. I have these genetics because I have Sami heritage and I am adapted to live in a cold climate and eating low purine, high zinc foods. Zinc also helps me break down the purines by stimulating LACC1, which is a sort of PNP backup. A zinc deficiency when I was young left me with an undecended testicle because of my LACC1 genetics.

https://www.uniprot.org/uniprotkb/Q8IV20/entry