There have been so very few space denizens, the science is in its infancy.
Space travel itself could be changed. For instance, a rocket to Mars may swing the habitat in a circle at the end of a miles-long wire to create artificial gravity. To those that claim 'acceleration is different from gravity', take your physics course again.
And people can be changed. It took a special kind of person to live at high altitude, and on an island with periodic feast-and-famine, and on a 2000 calorie rice diet, and in a crowded city, and on a submarine.
We can imagine (and often have in science fiction) a person built to crew long space missions. And we can imagine space missions designed for humans. Right now it's all in early days.