SARS-CoV-2-specific plasma cells not durably in bone marrow after mRNA vaccine

nature.com

9 pointscempaka2 comments

They say:

> In all, our studies suggest that rapid waning of SARS-CoV-2-specific serum antibodies could be accounted for by the absence of BM LLPCs after these mRNA vaccines.

But they also said:

> In five patients with known PCR-proven history of recent infection and vaccination, SARS-CoV-2-specific ASCs were mostly absent from the LLPCs.

Doesn’t that imply that all covid immunity, not just mRNA vaccines have this problem?

Not necessarily. perhaps Initial mRNA immunity was not completely comprehensive. as in only offered partial immunity and reduced symptoms, maybe this alters the later immune system structure on repeat infection.

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