100 Years of Solitude is my favorite. I majored in Spanish literature in college, that was my first exposure to Gabriel García Márquez (I read it in the original Spanish, but I'm told the English translation is faithful and very good).
Translated literature is interesting and I've recently read a few differing views on the "best" translations of Homer.
I've resigned myself that I simply must trust the masses in some places and I won't be learning Russian to read Tolstoy authentically.