2. You are purposely ignoring that: A) lots of them were unalived by the invaders and this has been going on on a more quieter manner until about 40-30 years ago which is not that long ago B)Columbus himself had to be arrested because even his resource-loving managers were horrified of the things he did there C) whole nations, tribes and cultures were wiped by the invaders D) the remaining natives in the northern bits lost of most of their lands and autonomy
None of this can be considered to be an inevitable result of trade. You can trade with a country without doing any of the above as can be seen by all the other countries that engaged in trade at that time. There is a moral element to all this that you are accidentally or purposefully ignoring. There is no need to compare it to any modern day conflict because even by today standards it was really evil and not all "inevitable".