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The only games I can't play on Linux are mega-modded Skyrim and League of Legends.

Not sure if 500 mods is "mega", but Skyrim runs fine using wine-staging. Indeed no issues with dx9 for a long time now.

Never tried LoL, but dx12 games like Horizon ZD/FW run well enough with ultra settings for the former, high for the latter.

I can at least confirm playing mega-modded Oblivion on Linux.