It's actually China, where sales account for 29% of global semiconductor sales, compared to 26% for the Americas (NA & SA).
https://www.semiconductors.org/wp-content/uploads/2024/10/SI... (PDF)
These are not as frequent or detailed as the SIA reports, but they are another source for comparison.
You can also check import/export/re-export statistics by industry and country using the International Trade Centre's Trade Map tool: https://www.trademap.org/Index.aspx
This does not include goods that are produced and used domestically.
The world economy is tightly interconnected, so almost any economic activity anywhere on Earth has at least some incidental, indirect connection to the US (and to China, and to the EU). Imposing such a wide-ranging secondary sanctions regime is extremely disruptive, and it's viewed by other countries as an attack on their sovereignty. When Trump pulled out of the Iran nuclear deal, he effectively forced the EU to also renege on the deal, because US sanctions banned virtually every EU company from doing business with Iran. The EU could no longer determine its own trade and foreign policy with Iran.
The answer to this is probably for other countries that want to retain their sovereignty to impose retaliatory sanctions on the US when it targets their companies. The EU is not sufficiently politically unified to do this, though, and most other countries/blocs (except for China) don't have the heft to go one-on-one against the US.
I wouldn't hold your breath.