My Ozempic Nightmare: I became sicker than ever instead of shedding pounds | Hacker News Reader

My Ozempic Nightmare: I became sicker than ever instead of shedding pounds

macleans.ca

4 pointsGeekette3 comments

If one spends any time on the various GLP-1 reddits you'll see plenty of these stories. It's clear that the current formulation or dosing regimen isn't ideal for everyone. That said, there is hope as there are multiple variations of the drugs now and more in the works. Part of the weight loss component of this drug happens in the brain and targeting that mechanism and developing formulations that mitigate nausea is almost certainly happening in labs across the world right now.

It will probably be the case that there will be a diverse set of offerings of these kind of drugs, with different priorities and people will just have to try each until they find the one that works best for them.

And if you spend any time critically reading them, you realize how many people are either exaggerating or not following the guidelines that exist.

Like this lady in the article. She did not follow dosing guidelines (which as you say are primitive at best at the moment) and tried to double her dose in half the time the guidelines and prescriptions state.

Since ozempic binds so strongly to the GLP receptor, this outcome is extremely common when moving up a dose. Especially earlier than indicated like she did.

These articles are almost all clickbait at this point. Very few illustrate someone carefully and intentionally using the drugs as intended in an informed manner. Moving up doses should be long considered, much less moving up early for what appears to be no reason at all against current medical advice. The social media posts are almost all even worse.

Tried it and it worked, I am type 2 diabetic at 210 pounds, all from lack of restraint. After 12 weeks I had lost 35 lbs, with no apparent side effects. MD check with an ECG showed all was good. A friend of mine also tried = severe side effects = he stopped it. Makes me wonder if people are dose sensitive? Reading online shows that click counting is a thing. Here is one at a children's hospital, who wanted ways to reduce dose for side effect reduction as well as for smaller children. google 'Ozempic click counting' to explore this rabbit hole. http://www.bcchildrens.ca/endocrinology-diabetes-site/docume...

The main way it worked was not finishing my plate = filling a smaller plate, as well as a longer interval before I thought of plates. Impulse snackery also ceased.

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