- hardware breakpoints on memory latch to logical, not physical addresses - one can map the same area of physical memory to different logical addresses thus allowing arbitrary memory reads - simulating inputs through the PnP stack can be made indetectible with polymorphic code doing the injections - detecting the aimbot's core code can be prevented via at least two methods: triggering (and capturing) page faults on memory hosting the bot or, again, with polymorphic code generation
One could create a fully open source cheat engine relying on memory reads and input injection via the pnp stavk and it would be undetectable deterministically (with heuristics, sure).
Games - unless streamed - need to know a bit more about the world they display than the player is allowed to see. Some engines I analysed (years ago) tried to limit propagating data to the local client to only a portion of the map and close proximity (the more recent battlefield games, if memory serves), while lots still have all enemy coordinates at all times in memory, some even with debug symbols to help the poor aimbot community reverse memory structures that more easily.
Its hopeless. The only winning move is not to play :-)