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That's usually the point at which I decide the project could really use being rewritten in C.

If I need performance badly enough that I'm considering making major structural changes in order to utilise multi-process or find some other way around the GIL, I probably ought to be considering using a language that supports what I'm trying to do. Of course my python projects tend to be fairly small.

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Or just write the fast bits in C, call it from Python via ctypes and get the GIL unlocked and parallelism for free.

If my projects were large enough to make that a more attractive option, sure, that's a great plan.

Usually when I've hit this situation I'm writing something simple but processor intensive, and it's easier for me (12 years commercial parallel/distributed C programming, amateur python enthusiast) to go back to home ground at this point.

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