My screen realestate changes several times a day. My work daily driver is a laptop that has a built in screen of a particular resolution. In the office it plugs into a dock with one monitor that has a different resolution than the built-in display. When I take it home and plug it into a dock it has two external monitors of different resolutions.

Icons need arrangements in each combination of monitors, resolutions, and scaling. So that when I'm sitting at my desk in the office I have a consistent experience of icon location. When I'm at home and have different screen layout, I can have a different icon layout suited to that screen layout and everytime I plug the dock in at home I should get the same arrangement that I had yesterday. If there's a new icon that has never been placed in a particular desk setup, drop it anywhere.