I think one can assume that at the level of this type of irreversible decision, said decision maker has thought long and hard about whether to "reassign their gender" and come to the conclusion most suitable for their own lives. At this point, it's only appropriate for close friends and family to perform a last questioning of sorts before the decision is sought through. I mean, there is a point at which you must make the switch from being skeptical of a situation to being accepting of the situation, or you must exit the situation (burn the bridge, etc). The point of acceptance after healthy skepticism is due to the fact that everyone's life is different, and there is no one-size-fits-all solution to any problem. The real trick is figuring out when and how to make that switch.