In this case, the library that buffers in userspace should set appropriate timers when it first buffers the data. Good choices of timeout parameter are: passed in as argument, slightly below human-scale (e.g. 1-100 ms), proportional to {bandwidth / threshold} (i.e. some multiple of the time it would take to reach the threshold at a certain access rate), proportional to target flushing overhead (e.g. spend no more than 0.1% time in syscalls).
Also note this applies for both writes and reads. If you do batched/coalesced reads then you likely want to do something similar. Though this is usually more dependent on your data channel as you need some way to query or be notified of “pending data” efficiently which your channel may not have if it was not designed for this use case. Again, pretty common in hardware to do interrupt coalescing and the like.