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A lack of selfishness at some level has the same problem as lack of an immune system. It encourages pathological behavior.

Too much has similar problems as an overactive immune system - it causes eventually self destructive pathologies.

Cooperation is also selfish, even if we don't normally think of it that way. We're working together with others to accomplish something we couldn't alone, but either the result is something we personally desire, or we expect compensation for our help.

Agreed. IMO, the real difference between ‘good’ (aka ‘not selfish’) and ‘bad’ (aka ‘selfish’) behavior is really more about the level of honesty, coercion, control, and degree of autonomy afforded the other participants than actual degree of self interest.

So it’s less about degree of one’s own self interest, and more about the degree of interfering with or manipulating others and their self-interests.

You might or might not be right, but even if you are, the extent to which this is depressing depends a lot on your definition (and delineation) of "self".

Peering deep enough amounts to making 'selfish' a meaningless word.