It seems to have a lot of resonance with trans people too. I'm autistic but there's enough overlap between the two groups that I've noticed how people in both communities react to the series.
I'm a man, so I went in with my prejudices and automatically assumed Murderbot is a "he". When reading a review that considered it a "she", I re-read most of it and there's no single indication of its gender, if Murderbot even assumes one.
I found that interesting, kind of like that trick Ursula K. Le Guin pulled when she didn't tell her readers Ged from Earthsea was dark skinned.
There are parts of the story where Murderbot passes as either a man or a woman so I figure the body shape must be fairly neutral.
Wow, I've only read the first one, but definitely considered Murderbot a she (even though I'm male). Hmmmm....
I do think it's unquestionable that she was purposefully subverting and playing with the standard expectations of fantasy novels written by white and male authors.
I think Martha Wells does a bit of the same with her depiction of both Murderbot as well as -- in general -- the role of women in her series. In particular Dr. Mensah impressed me: she's fair, intelligent, and in charge. She's not an action hero nor does she know her way around extreme violence, yet she's not downplayed as incompetent or lost (arguably after overcoming some initial naivete); in fact she's possibly the most competent character (in things other than killing people, of course).