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when will people decide it's time to go?They'll decide when they want to decide. Some might choose to actually live forever, and that's fine. Others will choose a more current-human type lifespan, and that's fine. Some will choose 150, some 300, some 1000, some 10,000. All of those numbers are fine.
> And how will they do it?
There are already humane forms of medical euthanasia performed in progressive places in the world; this question already has answers, and likely more will be developed over time. I don't think it's an important question or issue to discuss, as long as people have legal options.