The absence of clear selection pressure on certain RNA pairs doesn’t prove they lack function; many biological roles are subtle, context-dependent, or involve redundancy, making them difficult to detect with current methods. Freely mutating sequences could still influence genome architecture, gene regulation, or adaptation in ways not yet understood, as seen with elements like noncoding RNAs and transposable elements previously dismissed as “junk.” Additionally, these sequences may serve functions over long evolutionary or environmental time horizons, becoming critical under future conditions we cannot yet predict, underscoring the importance of not prematurely dismissing them.