I exclusively use mouse keys with my QMK keyboard [1] and I'm just as fast with it as with a mouse. I have four different cursor speeds that I toggle between as I move the mouse: I use the SUPA FAST LIGHTNING SPEED mode to move across the sceen and then reduce the speed as I zero in on my target. It's totally seamless and easy.
I also happen to use Tridactyl which uses a very similar mechanism as mouseless, but sometimes when I'm lazy I just use mouse keys. I don't think navigating by key anchors is always better: there's a greater cognitive load to reading off characters and typing them vs. using WASD to move your mouse around.
Alternatively, we could all simply relent and accept the fact that this problem was solved long ago in hardware and ship TrackPoints on all keyboards.