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I'm not a medical professional, but my understanding is that at least for the anti Alzheimer effect, it is due to the caffeine, specifically the effect it has on dilating capillaries in the brain.

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Does that work with other stimulants? Pretty much all the stronger ones dialate capillaries with fewer side effects than caffeine

What other stimulants do you have in mind? Ephedrine?

Eg Dextroamphetamine is well studied. A dose that causes the same capillary dilation as caffeine would have undetectable side effects

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