If I had to guess, it would be gravity sensors that render submarines obsolete.
Can't hide mass.
Can't hide mass.
I don't know about all the potential noise sources and how well any of them could be compensated for, but the raw sensory capacity of the best systems is at least enough to be worth considering the question.
Magnetic anomaly detectors have been used since the WWII airship days. https://en.m.wikipedia.org/wiki/Magnetic_anomaly_detector
Related fact: the first Goodyear blimp was a repurposed ex-Navy submarine hunter, that likely had a MAD device fitted. You can see the restored gondola from it in the New England Air Museum.
The Soviet Alpha, Mike and Sierra classes were built from titanium. Incredibly expensive but very deep-diving and invisible to MAD.