You should use (vanilla) Webkit or Chromium if you want to be really safe. As I'm sure you know perfectly well, Chrome is closed source and you really don't know what's going on inside it (Chromium, that is a different beast, is open source).
Chrome might be safer (than Safari, Firefox or IE) for this kind of malware, but I sure as hell wouldn't run a browser made by an company that makes money by collecting personal data for the benefit of advertisers if I wanted to be "safe". I see no reason to believe Microsoft, Apple or Google haven't put some spyware/backdoor in their browsers. But I really don't care about it, so I use Safari which is the best browser on Mac, IMO.