PyPI was always broken due to weird ideas for problems that were long solved in other languages or distributions. They had/have the backing of fastly.net, which created an arrogant and incompetent environment where people listed to no one.

Conda suffers from the virtual environment syndrome. Virtual environments are always imperfect and confusing. System libraries sometime leak through. The "scientific" Python stack has horrible mixtures of C/C++/Cython etc., all poorly written ad difficult to build.

Projects deteriorated in their ability to build from source due to the availability of binary wheels and the explosion of build systems. In 2010 there was a good chance that building a C project worked. Now you fight with meson versions, meson-python, cython versions, libc versions and so forth.

There is no longer any culture of correctness and code cleanliness in the Python ecosystem. A lot of good developers have left. Some current developers work for the companies who sell solutions for the chaos in the ecosystem.