What's most likely to happen is that they will punch it all into an excel sheet and get their primary objective of weight distribution correct. What will suffer is cargo organization so the crew at the layover is likely to find that they need to unload a bunch of stuff in order to get at some cargo that needs to come off at that stop.
A plane "could" fall out of the sky but that would require multiple people not doing their job but there's no point in pearl clutching over that because even if the software works the same people not doing their job can still cause that outcome.
[0] https://www.adn.com/alaska-news/aviation/2023/02/20/after-al...
The bug you cite, which you would not likely even know about if not for other commenters, was only caught because people asked for an old school manual calculation. Had the software process been more transparent it perhaps could have been caught earlier.
The fact that someone failed to properly implement the calculation in software does not change the efficacy of doing the calculation manually. Furthermore, the fact that there were people capable of eyeballing the accuracy of the software outputs seems to back up my point that there are tons of people capable of doing these calculations kicking around.
This is not rocket surgery. This is something that literally every private pilot with a Cessna does when they encounter a novel loading. Stop making it out to be some super scary thing requiring serious expertise to not screw up.