I still use containers for all that stuff that is not yet suitable for flatpaks (or perhaps never will be), just via distrobox or toolbox while leaving the host OS untouched
Did you consider Qubes OS? It's the same, except more secure/isolated and better UX than containers.
I did not at all consider it. I'm already pushing resource limits on my current machine as is. Adding vms to the mix would kill it. Also, that security doesn't come for free, it makes things that are currently easily, much more difficult for security I don't personally concern myself with.
Have they may giving gpu to things that need it easy yet?