i would not call myself an audiophile, per se, but i can hear the difference between a 128kbps MP3 and Opus 96kbps. same with $10 ear buds vs $150 iems, or my laptop's shitty 3.5mm stereo jack and a $30 usb dac.
once you get into stuff like $1K iems or dacs it's mostly bullshit (aside from brand/aesthetics, and things unrelated to audio fidelity). same with anyone claiming they can hear a difference between FLAC and Opus 160; trust me, you can't.