This video goes over how it’s not really that simple. Ultimately your body will cancel that deficit out https://youtu.be/vSSkDos2hzo
if you are already meeting that baseline, and still have issues, then you should look at tweaking other variables in the equation, whether diet, stress, etc.
What I find worrying is the cherry picking some people do, e.g. "aha your body will get used to exercise, so I might as well not bother", then wonder why at their next visit to the doctor, they are now told to go on a steady diet of statins etc.
That doesn't mean exercise isn't extremely important for your health. It is, in a myriad ways. Even the mechanisms that make it not help with weight loss are some of the reasons why it is so healthy - it's taking away calories from metabolic processes that are more harmful than helpful.