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Comment by DavideNL | Hacker News Reader

> but for me, the biggest quality of life improvements for me will be continued improvements with closed loop CGM + insulin pump systems

You might find this interesting: "A bi-hormonal fully closed loop system"

https://www.inredadiabetic.nl/en/home-english/

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Having talked with T1 diabetics about such systems, the issue is that you don’t want to deplete glycogen stores just for basal management. Because your life might depend on their levels in case of a severe hypo.

What exactly do you mean by "you don’t want to deplete glycogen stores" ?

It sounds like the system would release a hormone known as glucagon when blood sugar levels are too low. Glucagon triggers cellular pathways that break down glycogen stores into glucose molecules, and releases the glucose into the bloodstream. This is opposed to how diabetics handle it normally, by merely eating a sugary snack- however that takes longer to impact blood sugar levels. Depleting these stores could be catastrophic when they actually need a large amount of sugar to be dumped into the bloodstream

Disclaimer: not a doctor or biologist

Yes T1 here, those body glucose reserves shouldn't be used for regular control. They are reserves for exertion and emergencies. 42 years in, I'm fortunate with a high metabolism and I've always consumed fat as somewhat free extra calories. I use olive oil as a condiment I feel it gives me a standing energy reserve.

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