Nothing else provides a similar mix of security and usability. The alternatives are either much less secure or have much worse usability.
Of course only few people have these kinds of requirements. I'd recommend Qubes OS if you are an investigative journalist or working in offensive or defensive IT security. Everyone else can safely ignore it.
Still, even if it's not made for most of us it makes interesting design decisions that are very much of interest to this forum. And a lot of the people it is made for are here too
PS Qubes is Linux. The base domain hypervisor is Fedora-based, and while it is possible to run Windows in a "Qube," the docs and tooling clearly concentrate upon Linux (Fedora and Debian) as the primary use case.
This will let you run your email in one window, and click on a link to open it in another VM.
I've used it for a number of years.
You can install KDE, too: https://forum.qubes-os.org/t/kde-changing-the-way-you-use-qu...
It mostly runs Linux applications.