There's a theory that the mechanism of action of xenon and perhaps other anesthetics is on the microtubules rather than the receptors, having implications for the neural correlates of consciousness itself
https://www.nature.com/articles/s41598-017-09992-7
https://www.youtube.com/watch?v=QXElfzVgg6M
https://www.sciencedirect.com/science/article/abs/pii/S15710...