Fat cells 'remember' being bigger–and act like it

> When a person gains weight, the number of fat-storing cells in their body doesn’t change; instead, each one expands to store more fat within it by changing the way it responds to and stores nutrients.

Is this true? I thought the number of fat cells increase when you gain weight but don't decrease when you lose it.

https://pubmed.ncbi.nlm.nih.gov/29991030/

> A decrease in body weight only changes fat cell size (becoming smaller), whereas an increase in body weight causes elevation of both fat cell size and number in adults.

Supposedly adipocyte hyperplasia is even more common during childhood weight gain.

Link to the paper: https://www.nature.com/articles/s41586-024-08165-7

my fat cells never forgot so there is nothing to remember :)