The mystery being 'what causes ulcers', and the answer being Helicobacter pylori instead of stress.
Stress harms the immune system so many people who dramatically reduced stress showed meaningful improvement. One of those it’s better than a placebo treatments where the method of action was poorly understood.
It’s one of those cases where some bodies might just not be able to finish it off even in ideal conditions.
It’s a tricky thing in medicine. In then 90’s people discovered Leptin a hormone released by fat which when given to people dieting significantly reduced cravings and increased energy expenditure enabling long term weight loss. https://pmc.ncbi.nlm.nih.gov/articles/PMC2430504/
“rodents and humans that become obese on a high-fat (Western) diet do not respond to leptin” Unlike GLP-1 antagonists it did almost nothing to start the process of weight loss, but having a drug to give to people who lost 20+lb which would then help them keep it off could have helped a lot of people.