"Vitamin D3 and omega-3 fatty acids not helpful in reducing risk of frailty" https://medicalxpress.com/news/2022-09-vitamin-d3-omega-fatt...
"Vitamin D3 and omega-3 fatty acids not helpful in reducing risk of frailty" https://medicalxpress.com/news/2022-09-vitamin-d3-omega-fatt...
As I age, I increasingly see the effect that healthy people with great genetics also have all the indicators of being healthy. I think this effect is conflated to an extent even for things like exercise: for people that feel good and strong, exercise feels great. For people that aren't, they go downhill faster anyway.
I have terrible genetics for cardiovascular disease. I've spent my life as an athlete, eating healthy, training, etc. But now in my 30's, I can feel the slow down a lot despite being more disciplined in my training and diet than ever and yet I know people my age that haven't trained in years that can just go for a run and absolutely smoke me.
I'm sure at some point my genetics is going to force me to slow down a bit on the training despite my best efforts and then I'll just end up as someone contributing to the statistics that those who exercise more are healthier.
I know that exercise has benefits nevertheless, but I also think we very often just make the mistake of concluding "healthier people are healthier".
Life is not really fair.
That is not true. AFAIK there have been several studies using supplements of Vitamin D3 & Omega-3 that showed that it improved biomarkers of various diseases.
Similar significant results for symptoms of cystic fibrosis: https://pubmed.ncbi.nlm.nih.gov/32275788/
most cells have vitamin D receptors, so I would think it is actually a driver
Some vitamin D skeptics claim tat there's insufficient evidence from RCTs but few people question the causality of smoking's influence on cancer despite no RCTs for that---that relationship was established also via Hill's Criteria.
Both my statement and yours can be true. Having a deficiency in an essential nutrient can be causal for bad outcomes while, at the same time, having the correct amount or excess can be non-causal but correlated with positive health outcomes.
It doesn’t mean that either paper’s claims or results are automatically invalid
Research is hard