It was always strange to me that scientists (people that are expected to be rigorous in their experimentation and analysis) would not include history in their analysis.

However, the Latin root of the word "science" is about cutting or taking something apart and zooming in. Perhaps another word is needed to describe the process of putting whatever is scientifically discovered within a larger context to account for so many variables that are ignored during the scientific process.

I personally suspect that all the biomarker stuff are really just the biochemical remnants of processes that begin at the sociocultural level.