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Comment by wewewedxfgdf | Hacker News Reader

I'm far from convinced that some random "compounding pharmacy" produces effectively the same thing as Ozempic.

Compounding pharmacies existed before Ozempic and their entire business model is producing custom drugs at reasonable prices. For Ozempic, they order the GLP-1 peptides from a large Pharma company and then mix it to order with bacteriostatic water and any other additives. Mine includes a B-12 compound that is attempting to help with the weight loss. They are highly regulated and require trained and licensed employees. The compounding pharmacies I don't trust are the ones that only started to do Ozempic and nothing else. But I do trust my local one. They've made me medication for my animals for decades now.

Is there a compounding pharmacy aggregator online youve found trustworthy?

https://www.glpwinner.com/ is a good resource for comparing compound glp-1 providers

> They are highly regulated and require trained and licensed employees. The compounding pharmacies I don't trust are the ones that only started to do Ozempic and nothing else.

We already know that the compounding pharmacies violate patent law. Why should I believe they follow any other regulation?

The thing is, GLP-1 isn't that hard to make, and these compounding pharmacies make effectively the real thing.

Even further, most drugs aren't _that hard_ to manufacturer.

The hard part is discovering them and proving they're safe and effective.

What would convince you?

Some of those pharmacies were using crushed Rybelsus as their source for semaglutude.

What do you believe is different between their process and the patent holders?

They don't need to recoup their investments in discovery and regulatory approval.

What do we believe the discovery pathway was? Billions of dollars spent by heady businessmen with a keen eye for the molecules of interest? Hardly:

https://www.pnas.org/doi/10.1073/pnas.2415550121

And this type of drug lends itself to some of the least expensive trials you can hope for. The dosage level, expected dosing period, and measurement of outcomes are all uniquely well suited to inexpensive study. The trials were also exceedingly fast and quickly broke off into testing for all kinds of conditions such as Parkinsons but for the core case of weight loss it was as easy as it gets.

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