Map the human genome or build the next Farmville?
Find a way to grow food 300% more efficiently to meet the growing demands of the world population or make an iPhone app?
Why must everything be internet-based and somehow have to best Google?
Additionally, I think the author is having trouble filtering out the so called "noise" from the signal. I, for one, think it's terrific that a whole new class of small or "mom and pop" businesses can now exist on the Internet. Does that give us huge advancements as a species? Usually not, but hopefully it's paying their rent, which is great for them.
Yes, we need big ideas to move forward, but don't begrudge the next generation of Internet-based small businesses. The people starting these business are probably NOT the same people who would come up with the earth-changing idea that the author so desperately wants. And if you are one of those select few, then please, stay hungry and stay foolish.