It would catch them off guard, and then I would point out that they have faith in transhumanism like Christians have faith in Jesus. There would be a quick "get it" facial expression, then we'd both laugh. The transhumanists who I encountered were opened-minded enough to realize the difference between faith and reason.
I'd then point out that the Egyptians had similar beliefs, and say that if you freeze your body, or head, at death; most likely someone would use it for some strange science experiment in the future.
That being said, if I was wealthy, I'd love to freeze my body. I'm sure it'll come in handy for someone at some point, just like Egyptian mummies did.